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- Title
Tafenoquine-Based Combination Therapies: A Step Toward Babesiosis Elimination.
- Authors
Liu, Mingming; Galon, Eloiza May; Ji, Shengwei; Xuan, Xuenan
- Abstract
A study published in the Journal of Infectious Diseases discusses the potential of tafenoquine-based combination therapies for the elimination of babesiosis. The study highlights the effectiveness of tafenoquine and atovaquone combination over existing treatments and its potential role in providing protective immunity. However, challenges still remain. The article also mentions the recommended antimicrobial treatments for babesiosis and the contraindications of tafenoquine in individuals with glucose-6-phosphate dehydrogenase deficiency. The mechanism of tafenoquine's action against Babesia parasites is not fully understood, but it may involve drug-induced oxidative stress. The article emphasizes the importance of identifying drug targets and clarifying the mechanism of tafenoquine's activity to prevent the emergence of drug resistance.
- Subjects
BABESIOSIS; GLUCOSE-6-phosphate dehydrogenase deficiency; ORAL drug administration
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 5, p1599
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiae083