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- Title
HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV.
- Authors
Benner, Sarah E; Zhu, Xianming; Hussain, Sarah; Florman, Sander; Eby, Yolanda; Fernandez, Reinaldo E; Ostrander, Darin; Rana, Meenakshi; Ottmann, Shane; Hand, Jonathan; Price, Jennifer C; Pereira, Marcus R; Wojciechowski, David; Simkins, Jacques; Stosor, Valentina; Mehta, Sapna A; Aslam, Saima; Malinis, Maricar; Haidar, Ghady; Massie, Allan
- Abstract
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.
- Subjects
LIVER transplantation; CLINICAL trial registries; HIV; HIV-positive persons
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 9, p1274
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad241