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Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype.
Published in:
2012
By:
- Seegers J;
- Vos MA;
- Flevari P;
- Willems R;
- Sohns C;
- Vollmann D;
- Lüthje L;
- Kremastinos DT;
- Floré V;
- Meine M;
- Tuinenburg A;
- Myles RC;
- Simon D;
- Brockmöller J;
- Friede T;
- Hasenfuß G;
- Lehnart SE;
- Zabel M;
- EUTrigTreat Clinical Study Investigators;
- Seegers, Joachim
Publication type:
journal article
The genetics of loop diuretic effects.
Published in:
Pharmacogenomics Journal, 2012, v. 12, n. 1, p. 45, doi. 10.1038/tpj.2010.68
By:
- Vormfelde, S V;
- Brockmöller, J
Publication type:
Article
Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT<sub>3</sub> antagonists tropisetron and ondansetron.
Published in:
Pharmacogenomics Journal, 2012, v. 12, n. 1, p. 22, doi. 10.1038/tpj.2010.75
By:
- Tzvetkov, M V;
- Saadatmand, A R;
- Bokelmann, K;
- Meineke, I;
- Kaiser, R;
- Brockmöller, J
Publication type:
Article
Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.
Published in:
Pharmacogenomics Journal, 2008, v. 8, n. 4, p. 297, doi. 10.1038/sj.tpj.6500467
By:
- Schirmer, M.;
- Hoffmann, M.;
- Kaya, E.;
- Tzvetkov, M.;
- Brockmöller, J.
Publication type:
Article
Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication.
Published in:
Pharmacogenomics Journal, 2007, v. 7, n. 4, p. 257, doi. 10.1038/sj.tpj.6500406
By:
- Kirchheiner, J.;
- Schmidt, H.;
- Tzvetkov, M.;
- Keulen, J-THA;
- Lötsch, J.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Genetic variation at the CYP2C locus and its association with torsemide biotransformation.
Published in:
Pharmacogenomics Journal, 2007, v. 7, n. 3, p. 200, doi. 10.1038/sj.tpj.6500410
By:
- Vormfelde, S. V.;
- Schirmer, M.;
- Toliat, M. R.;
- Meineke, I.;
- Kirchheiner, J.;
- Nürnberg, P.;
- Brockmöller, J.
Publication type:
Article
A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment.
Published in:
Pharmacogenomics Journal, 2007, v. 7, n. 1, p. 48, doi. 10.1038/sj.tpj.6500398
By:
- Kirchheiner, J.;
- Nickchen, K.;
- Sasse, J.;
- Bauer, M.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function.
Published in:
Molecular Psychiatry, 2013, v. 18, n. 3, p. 273, doi. 10.1038/mp.2012.42
By:
- Stingl, J C;
- Brockmöller, J;
- Viviani, R
Publication type:
Article
The interleukin-10 gene promoter polymorphism −1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.
Published in:
Genes & Immunity, 2007, v. 8, n. 2, p. 164, doi. 10.1038/sj.gene.6364364
By:
- Kube, D.;
- Hua, T.-D.;
- Klöss, M.;
- Kulle, B.;
- Brockmöller, J.;
- Wojnowski, L.;
- Löffler, M.;
- Pfreundschuh, M.;
- Trümper, L.
Publication type:
Article
CYP2D6 and tamoxifen: pharmacogenetic reinvention of an established drug?
Published in:
2009
By:
- von Ahsen N;
- Binder C;
- Brockmöller J;
- Oellerich M
Publication type:
Journal Article
Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug Tramadol.
Published in:
Clinical Pharmacology & Therapeutics, 2011, v. 90, n. 1, p. 143, doi. 10.1038/clpt.2011.56
By:
- Tzvetkov, M. V.;
- Saadatmand, A. R.;
- Lötsch, J.;
- Tegeder, I.;
- Stingl, J. C.;
- Brockmöller, J.
Publication type:
Article
Why, When, and How Should Pharmacogenetics Be Applied in Clinical Studies?: Current and Future Approaches to Study Designs.
Published in:
Clinical Pharmacology & Therapeutics, 2011, v. 89, n. 2, p. 198, doi. 10.1038/clpt.2010.274
By:
- Stingl, J. C.;
- Brockmöller, J.
Publication type:
Article
The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin.
Published in:
Clinical Pharmacology & Therapeutics, 2009, v. 86, n. 3, p. 299, doi. 10.1038/clpt.2009.92
By:
- Tzvetkov, M. V.;
- Vormfelde, S. V.;
- Balen, D.;
- Meineke, I.;
- Schmidt, T.;
- Sehrt, D.;
- Sabolić, I.;
- Koepsell, H.;
- Brockmöller, J.
Publication type:
Article
Relative Impact of Genotype and Enzyme Induction on the Metabolic Capacity of CYP2C9 in Healthy Volunteers.
Published in:
Clinical Pharmacology & Therapeutics, 2009, v. 86, n. 1, p. 54, doi. 10.1038/clpt.2009.40
By:
- Vormfelde, S. V.;
- Brockmöller, J.;
- Bauer, S.;
- Herchenhein, P.;
- Kuon, J.;
- Meineke, I.;
- Roots, I.;
- Kirchheiner, J.
Publication type:
Article
Interindividual Variation in the Pharmacokinetics of Δ9-Tetrahydrocannabinol as Related to Genetic Polymorphisms in CYP2C9.
Published in:
Clinical Pharmacology & Therapeutics, 2009, v. 85, n. 3, p. 273, doi. 10.1038/clpt.2008.213
By:
- Sachse-Seeboth, C.;
- Pfeil, J.;
- Sehrt, D.;
- Meineke, I.;
- Tzvetkov, M.;
- Bruns, E.;
- Poser, W.;
- Vormfelde, S. V.;
- Brockmöller, J.
Publication type:
Article
The Polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 Allele *3 Independently Affect Torsemide Pharmacokinetics and Pharmacodynamics.
Published in:
2008
By:
- Vormfelde, S. V.;
- Toliat, M. R.;
- Schirmer, M.;
- Meineke, I.;
- Nürnberg, P.;
- Brockmöller, J.
Publication type:
Letter
Population Pharmacokinetics of Melphalan and Glutathione S-transferase Polymorphisms in Relation to Side Effects.
Published in:
Clinical Pharmacology & Therapeutics, 2008, v. 83, n. 5, p. 749, doi. 10.1038/sj.clpt.6100336
By:
- Kühne, A.;
- Sezer, O.;
- Heider, U.;
- Meineke, I.;
- Muhlke, S.;
- Niere, W.;
- Overbeck, T.;
- Hohloch, K.;
- Trümper, L.;
- Brockmöller, J.;
- Kaiser, R.
Publication type:
Article
Genetic Variation in the Renal Sodium Transporters NKCC2, NCC, and ENaC in Relation to the Effects of Loop Diuretic Drugs.
Published in:
Clinical Pharmacology & Therapeutics, 2007, v. 82, n. 3, p. 300, doi. 10.1038/sj.clpt.6100131
By:
- Vormfelde, S. V.;
- Sehrt, D.;
- Toliat, M. R.;
- Schirmer, M.;
- Meineke, I.;
- Tzvetkov, M.;
- Nürnberg, P.;
- Brockmöller, J.
Publication type:
Article
Pharmacokinetics of Mirtazapine: Enantioselective Effects of the CYP2D6 Ultra Rapid Metabolizer Genotype and Correlation with Adverse Effects.
Published in:
Clinical Pharmacology & Therapeutics, 2007, v. 81, n. 5, p. 699, doi. 10.1038/sj.clpt.6100116
By:
- Brockmöller, J.;
- Meineke, I.;
- Kirchheiner, J.
Publication type:
Article
Pharmacogenetics of loop diuretics.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P63, doi. 10.1016/j.clpt.2003.11.239
By:
- Vormfelde, S. V.;
- Zirk, A.;
- Westermann, J.;
- Torn, M.;
- Tuchen, F.;
- Toliat, M. R.;
- Brockmöller, J.
Publication type:
Article
Relationship between CYP2C9 genetic polymorphisms and effects of the loop diuretic torasemide.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P66, doi. 10.1016/j.clpt.2003.11.249
By:
- Vormfelde, S. V.;
- Zirk, A.;
- Westermann, J.;
- Kirchheiner,, J. C.;
- Brockmöller, J.
Publication type:
Article
On the impact of the CYP2D6 ultra-rapid metabolizer genotype on mirtazapine pharmacokinetics.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P67, doi. 10.1016/j.clpt.2003.11.250
By:
- Brockmöller, J.;
- Kirchheiner, J.;
- Henckel, H.;
- Meineke, I.;
- Roots, I.
Publication type:
Article
Impact of CYP3A haplotypes on alprazolam kinetics with and without rifampicin induction.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P81, doi. 10.1016/j.clpt.2003.11.311
By:
- Goldammer, M.;
- Kirchheiner, J.;
- Bauer, S.;
- Terhalle, W.;
- Meisel, C.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Metoprolol pharmacokinetics and pharmacodynamics in carriers of CYP2D6 genotypes predicting ultra-rapid metabolism.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P19, doi. 10.1016/j.clpt.2003.11.070
By:
- Kirchheiner, J.;
- Meisel, C.;
- Heesch, C.;
- Bauer,, S.;
- Keulen, T.;
- Henckel, H.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Enantio-preferential effects of the CYP2D6 genotype on bioavailability and systemic clearance of the tricyclic antidepressant trimipramine.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 2, p. P19, doi. 10.1016/j.clpt.2003.11.071
By:
- Kirchheiner, J.;
- Meineke, I.;
- Brockmöller, J.;
- Roots, I.
Publication type:
Article
Variability of bupropion pharmacokinetics in relation to amino acid polymorphisms in CYP2B6.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P56, doi. 10.1016/S0009-9236(03)90564-9
By:
- Brockmöller, J.;
- Kirchheiner, J.;
- Klein, C.;
- Sasse, J.;
- Roots, I.
Publication type:
Article
Impact of the CYP2C9 and CYP2D6 polymorphisms for pharmacokinetics of 3R,5S- and 3S,5R fluvastatin.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P75, doi. 10.1016/S0009-9236(03)90634-5
By:
- Kirchheiner, J.;
- Kudlicz, D.;
- Meisel, C.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Comparison of the impact of the CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of the NSAIDS celecoxib, diclofenac, and ibuprofen.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P75, doi. 10.1016/S0009-9236(03)90635-7
By:
- Kirchheiner, J.;
- Meineke, I.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Influence of CYP2C9 amino acid polymorphisms on enantioselective metabolism of R-,S-phenprocoumon.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P76, doi. 10.1016/S0009-9236(03)90636-9
By:
- Roots, I.;
- Kirchheiner, J.;
- Walter, E.;
- Kammerer, B.;
- Schwab, M.;
- Meisel, C.;
- Brockmöller, J.
Publication type:
Article
Impact of CYP2C9 amino acid variants Arg144Cys and Ile359Leu on the pharmacokinetics and pharmacodynamics of nateglinide.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 2, p. P76, doi. 10.1016/S0009-9236(03)90637-0
By:
- Brockmöller, J.;
- Kirchheiner, J.;
- Müller, G.;
- Meineke, I.;
- Meisel, C.;
- Roots, I.
Publication type:
Article
Gene-environment synergisms in bladder cancer risk: Arylamine n-acetyltransferase type 2, smoking and occupation.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 2, p. 169, doi. 10.1038/sj.clpt.1996.174
By:
- Brockmöller, J.;
- Cascorbi, I.;
- Roots, I.
Publication type:
Article
Heritable deficiency of glutathione S-transferases T1 and M1 and UV-light sensitivity of the skin.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 2, p. 169, doi. 10.1038/sj.clpt.1996.175
By:
- Roots, I.;
- Kerb, R.;
- Brockmöller, J.
Publication type:
Article
The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
Published in:
Translational Psychiatry, 2016, v. 6, n. 11, p. e937, doi. 10.1038/tp.2016.187
By:
- Biernacka, J M;
- Sangkuhl, K;
- Jenkins, G;
- Whaley, R M;
- Barman, P;
- Batzler, A;
- Altman, R B;
- Arolt, V;
- Brockmöller, J;
- Chen, C H;
- Domschke, K;
- Hall-Flavin, D K;
- Hong, C J;
- Illi, A;
- Ji, Y;
- Kampman, O;
- Kinoshita, T;
- Leinonen, E;
- Liou, Y J;
- Mushiroda, T
Publication type:
Article
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis.
Published in:
Carcinogenesis, 2003, v. 24, n. 5, p. 875
By:
- S. Anttila;
- I. Kalina;
- L. Le Marchand;
- S.J. London;
- A. Rannug;
- M. Romkes;
- J. Salagovic;
- B. Schoket;
- L. Gaspari;
- E. Taioli;
- R.J. Hung;
- P. Boffetta;
- J. Brockmöller;
- D. Butkiewicz;
- I. Cascorbi;
- M.L. Clapper;
- S. Garte;
- A. Haugen;
- A. Hirvonen
Publication type:
Article
Stand der Pharmakogenetik in der klinischen Arzneimitteltherapie.
Published in:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2006, v. 49, n. 10, p. 995, doi. 10.1007/s00103-006-0045-1
By:
- Kirchheiner, J.;
- Seeringer, A.;
- Brockmöller, J.
Publication type:
Article
Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro.
Published in:
Psychopharmacology, 2000, v. 151, n. 4, p. 312
By:
- Störmer, E.;
- Brockmöller, J.;
- Roots, I.;
- Schmider, J.
Publication type:
Article
Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2.
Published in:
Clinical Pharmacology & Therapeutics, 2016, v. 100, n. 6, p. 606, doi. 10.1002/cpt.444
By:
- Matthaei, J;
- Tzvetkov, MV;
- Strube, J;
- Sehrt, D;
- Sachse‐Seeboth, C;
- Hjelmborg, JB;
- Möller, S;
- Halekoh, U;
- Hofmann, U;
- Schwab, M;
- Kerb, R;
- Brockmöller, J
Publication type:
Article
OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics.
Published in:
Clinical Pharmacology & Therapeutics, 2016, v. 99, n. 6, p. 633, doi. 10.1002/cpt.317
By:
- Matthaei, J;
- Kuron, D;
- Faltraco, F;
- Knoch, T;
- Dos Santos Pereira, JN;
- Abu Abed, M;
- Prukop, T;
- Brockmöller, J;
- Tzvetkov, MV
Publication type:
Article
Heritability of Metoprolol and Torsemide Pharmacokinetics.
Published in:
Clinical Pharmacology & Therapeutics, 2015, v. 98, n. 6, p. 611, doi. 10.1002/cpt.258
By:
- Matthaei, J;
- Brockmöller, J;
- Tzvetkov, MV;
- Sehrt, D;
- Sachse‐Seeboth, C;
- Hjelmborg, JB;
- Möller, S;
- Halekoh, U;
- Hofmann, U;
- Schwab, M;
- Kerb, R
Publication type:
Article
Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH.
Published in:
2009
By:
- Kirchheiner J;
- Glatt S;
- Fuhr U;
- Klotz U;
- Meineke I;
- Seufferlein T;
- Brockmöller J
Publication type:
Journal Article
Association between CYP2C9 slow metabolizer genotypes and severe hypoglycaemia on medication with sulphonylurea hypoglycaemic agents.
Published in:
British Journal of Clinical Pharmacology, 2005, v. 60, n. 1, p. 103, doi. 10.1111/j.1365-2125.2005.02379.x
By:
- Holstein, A.;
- Plaschke, A.;
- Ptak, M.;
- Egberts, E.-H.;
- El-Din, J.;
- Brockmöller, J.;
- Kirchheiner, J.
Publication type:
Article
Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine.
Published in:
British Journal of Clinical Pharmacology, 2002, v. 54, n. 6, p. 592, doi. 10.1046/j.1365-2125.2002.t01-1-01689.x
By:
- Meineke, Ingolf;
- Freudenthaler, Stefan;
- Hofmann, Ute;
- Schaeffeler, Elke;
- Mikus, Gerd;
- Schwab, Matthias;
- Prange, Hilmar W.;
- Gleiter, Christoph H.;
- Brockmöller, J.
Publication type:
Article
Personalisierte Arzneitherapie auf genetischer Grundlage.
Published in:
Der Internist, 2016, v. 57, n. 3, p. 289, doi. 10.1007/s00108-015-0013-7
By:
- Stingl, J.;
- Just, K.;
- Kaumanns, K.;
- Schurig-Urbaniak, M.;
- Scholl, C.;
- von Mallek, D.;
- Brockmöller, J.
Publication type:
Article
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response.
Published in:
Molecular Psychiatry, 2004, v. 9, n. 5, p. 442, doi. 10.1038/sj.mp.4001494
By:
- Kirchheiner, J.;
- Nickchen, K.;
- Bauer, M.;
- Wong, M. -L.;
- Licinio, J.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia.
Published in:
Molecular Psychiatry, 2001, v. 6, n. 2, p. 179, doi. 10.1038/sj.mp.4000821
By:
- Kaiser, R.;
- Tremblay, P.-B.;
- Schmider, J.;
- Henneken, M.;
- Dettling, M.;
- Müller-Oerlinghausen, B.;
- Uebelhack, R.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia.
Published in:
Molecular Psychiatry, 2000, v. 5, n. 4, p. 418, doi. 10.1038/sj.mp.4000729
By:
- Kaiser, R.;
- Könneker, M.;
- Henneken, M.;
- Dettling, M.;
- Müller-Oerlinghausen, B.;
- Roots, I.;
- Brockmöller, J.
Publication type:
Article
Personalisierte Pharmakotherapie.
Published in:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2013, v. 56, n. 11, p. 1509, doi. 10.1007/s00103-013-1822-2
By:
- Stingl, J.C.;
- Brockmöller, J.
Publication type:
Article
CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants:a first step towards subpopulation-specific dosages.
Published in:
Acta Psychiatrica Scandinavica, 2001, v. 104, n. 3, doi. 10.1034/j.1600-0447.2001.00299.x
By:
- Kirchheiner, J.;
- Brøsen, K.;
- Dahl, M. L.;
- Gram, L. F.;
- Kasper, S.;
- Roots, I.;
- Sjöqvist, F.;
- Spina, E.;
- Brockmöller, J.
Publication type:
Article

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