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- Title
Diabetes-associated HLA-DQ genes and birth weight.
- Authors
Stene, Lars C.; Magnus, Per; Rønningen, Kjersti S.; Joner, Geir; Stene, L C; Magnus, P; Rønningen, K S; Joner, G
- Abstract
An association has recently been described between increased birth weight and increased risk of childhood-onset type 1 diabetes. Whether this relationship is explained by genes associated with both increased birth weight and increased risk of type 1 diabetes is unknown. In the present study, we tested the association between birth weight and HLA-DQ genotypes known to confer risk for type 1 diabetes among 969 nondiabetic children randomly selected from the Norwegian population. We found that HLA genotypes previously shown to confer risk for type 1 diabetes were associated with reduced birth weight (the mean difference in birth weight between the DQB1*0602/DQB1*0602 and DQ8/DQ2 genotypes was 354 g [95% CI 105-604]), which was opposite of that expected if HLA genes explained the birth weight-type 1 diabetes association.
- Subjects
BIRTH weight; GENETICS of diabetes; COMPARATIVE studies; DISEASE susceptibility; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; RESEARCH; HLA-B27 antigen; EVALUATION research; MEMBRANE glycoproteins
- Publication
Diabetes, 2001, Vol 50, Issue 12, p2879
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.50.12.2879