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- Title
Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus.
- Authors
Ivarsson, Sten-A.; Marner, Bente; Lernmark, Åke; Nilsson, Karl Olof; Ivarsson, S A; Marner, B; Lernmark, A; Nilsson, K O
- Abstract
Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw3/4-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.
- Publication
Diabetes, 1988, Vol 37, Issue 3, p347
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.37.3.347