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- Title
Yolk Sac Tumor in a Recurrence of Colonic Adenocarcinoma With Shared Mutations in APC and TP53 Genes: A Case Report.
- Authors
Otani, Tomoyuki; Kanemura, Hiroaki; Kimura, Masatomo; Mitani, Seiichiro; Takeda, Masayuki; Matsuki, Mitsuru; Matsumura, Noriomi; Satou, Takao; Nakagawa, Kazuhiko; Ito, Akihiko
- Abstract
Only four cases of colorectal adenocarcinoma with a yolk sac tumor (YST) component have been reported in the English literature. No genetic investigation has been performed in these cases. We report a case of colorectal adenocarcinoma in which the recurrent tumor had a YST component. A 49-year-old woman presented with a pelvic tumor three years after endoscopic mucosal resection of sigmoid colon adenocarcinoma. The pelvic tumor consisted of an undifferentiated carcinoma component and a YST component. The serum alpha-fetoprotein level was elevated to 42 ng/mL. Treatment as conventional colorectal carcinoma produced some anticancer effects, but the patient died 14 months after the recurrence and 49 months after the EMR. With the help of the next-generation sequencing results of the recurrent tumor, APC c.835 − 8A > G and TP53 c.524G > A (p.R175H) mutations were identified by direct sequencing in both the primary and the recurrent tumors, confirming the relationship between the two metachronous tumors.
- Subjects
COLON tumors; DISEASE relapse; PELVIC tumors; CARCINOMA; SIGMOID colon; ALPHA fetoproteins; SOMATIC mutation
- Publication
International Journal of Surgical Pathology, 2022, Vol 30, Issue 6, p646
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969211069963