We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
PRELIMINARY STUDY TOWARDS A NOVEL EXPERIMENTAL MODEL TO STUDY LOCALIZED CUTANEOUS LEISHMANIASIS CAUSED BY Leishmania (Leishmania) mexicana.
- Authors
Sosa-Bibiano, Erika Ivett; Van Wynsberghe, Nicole Raymonde; Canto-Lara, Silvia Beatriz; Narvaezandrade, Fernando Jose
- Abstract
There is not an experimental model of localized cutaneous leishmaniasis (LCL) caused by Leuhmania (Leishmania) mexicana. The aim of the present study was to characterize the clinical and histological features of Peromyscus yucatanicus experimentally infected with L. (L.) mexicana. A total of 54 P. yucatanicus (groups of 18) were inoculated with 1×lO6 promastigotes of L. (L.) mexicana in the base of the tail. They were euthanized at three and six months post experimental infection. The control group was inoculated with RPMI-1640. The predominant clinical sign observed was a single ulcerated lesion in 27.77% (5/18) and in 11.11% (2/18) P yucatanicus at three and six months respectively. The histological pattern described as chronic granulomatous inflammation with or without necrosis was found in 7/7 (100%) biopsies of euthanized P. yucatanicus at three (n = 5) and six (n = 2) months, respectively. These results resembled clinical and histological features caused by L. (L.) mexicana in humans, and support the possibility to employ P. yucatanicus as a novel experimental model to study LCL caused by this parasite.
- Subjects
CUTANEOUS leishmaniasis; LEISHMANIA mexicana; PEROMYSCUS yucatanicus; PROMASTIGOTE; CONTROL groups; INFLAMMATION; BIOPSY
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2012, Vol 54, Issue 3, p165
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S0036-46652012000300009