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- Title
CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population.
- Authors
Wang, Da-dong; Duan, Wei-dong; Zhu, Zi-man; Tu, Yu-liang; Dou, Chun-qing; Han, Ming-ming; Zhang, Bao; Zhao, Wei; Jiang, Kai
- Abstract
<bold>Aims: </bold>Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship.<bold>Materials and Methods: </bold>Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis).<bold>Results: </bold>We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88-1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05-2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71-1.18).<bold>Conclusions: </bold>This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians.
- Subjects
GENETIC polymorphisms; LIVER cancer; PUBMED (Online service); ODDS ratio; CONFIDENCE intervals; ALLELES; ASIANS; COMPARATIVE studies; DISEASE susceptibility; GENETIC techniques; HEPATOCELLULAR carcinoma; LIVER tumors; RESEARCH methodology; MEDICAL cooperation; META-analysis; PROTEINS; RESEARCH; RISK assessment; WHITE people; EVALUATION research; CASE-control method; PUBLICATION bias
- Publication
Journal of Cancer Research & Therapeutics, 2018, Vol 14, p516
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.203598