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- Title
The association between myeloperoxidase 463G>A polymorphisms and risk of lung cancer in East-Asia population.
- Authors
Xin Hou; Yuhua Gao; Yongjian Duan; Zhiwei Wang; Lei Shi; Jincheng Ma; Xuanhu Xie
- Abstract
Objective: The association between the myeloperoxidase (MPO) 463 G>A polymorphism and lung cancer risk remains controversial. We perform this meta-analysis to further evaluate the MPO 463G>A polymorphism and lung cancer susceptibility. Materials and Methods: We performed the systemic literature search in PubMed, EMBASE, WANFANG, and CNKI databases for molecular epidemiologic studies on the association of MPO 463G>A polymorphism and lung cancer susceptibility. The pooled odds ratio (OR) of MPO 463G>A polymorphism and lung cancer risk were calculated by random or fixed effect model. Results: Seven case-control studies including 1538 lung cancer patients in the case group and 1673 healthy controls in the control group were included in this study. MPO 463G>A polymorphism was not associated with lung cancer susceptibility under the condition of recessive genetic model (AA vs. GG+GA) (OR = 0.69, P > 0.05) and homozygous genetic model (AA vs. GG) (OR = 0.65, P > 0.05). However, we found significantly decreased risk of lung cancer under dominant genetic model (GA+AA vs. GG) (OR = 0.84, P < 0.05). And no publication bias was found in this meta-analysis for the three genetic models (P > 0.05). Conclusion: This meta-analysis indicated that people with AA genetic type may have decreased lung cancer risk under dominant genetic model.
- Subjects
MYELOPEROXIDASE; LUNG cancer diagnosis; GENETIC polymorphisms; LUNG cancer patients; MEDICAL databases; LUNG cancer treatment
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, pC97
- ISSN
0973-1482
- Publication type
Article
- DOI
10.4103/0973-1482.163854