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- Title
Association of Dental Fluorosis with Polymorphisms of Estrogen Receptor Gene in Chinese Children.
- Authors
Ba, Yue; Zhang, Huizhen; Wang, Gang; Wen, Shibao; Yang, Yuejin; Zhu, Jingyuan; Ren, Lijun; Yang, Rupu; Zhu, Cairong; Li, Haixia; Cheng, Xuemin; Cui, Liuxin
- Abstract
Dental fluorosis (DF) is one of the important performances of endemic fluorosis. Some studies indicated that estrogen receptor ( ESR) gene polymorphisms were associated with bone metabolism-related diseases. Therefore, it is possible that the variation in ESR genotypes will be associated with DF status. A case-control study was conducted among children aged 8-12 years with ( n = 75) or without ( n = 165) DF in China to investigate the relationship between ESR gene polymorphisms and DF. Gene polymorphisms were genotyped using the PCR-RFLP procedure. Children carrying R allele of ER RsaI had significantly increased risk of DF (Odds ratio (OR) = 1.821; 95% confidence interval (CI), 1.013-3.274) compared to children carrying r allele of ER RsaI in endemic fluorosis villages. For children with high-loaded fluoride status, carrying X allele of ESRα XbaI had a significantly decreased risk of DF (OR = 0.542; 95% CI, 0.314-0.936) compared to carrying x allele. This study provides the first evidence of an association between polymorphisms in the ESR gene with DF in high-fluoride-exposed populations. Further studies are needed to confirm the association.
- Subjects
ESTROGEN receptors; FLUOROSIS; GENES; FLUORIDES; CAVITY prevention
- Publication
Biological Trace Element Research, 2011, Vol 143, Issue 1, p87
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-010-8848-1