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- Title
Force-length relation of skeletal muscles: from sarcomeres to myofibril.
- Authors
Hou, M.
- Abstract
Sarcomeres are building blocks of skeletal muscles. Given force-length relations of sarcomeres serially connected in a myofibril, the myofibril force-length relation can be uniquely determined. Necessary and sufficient conditions are derived for capability of fully lengthening or completely shortening a myofibril under isometric, eccentric or concentric contraction, and for the myofibril force-length relation to be a continuous single-valued function. Intriguing phenomena such as sarcomere force-length hysteresis and myofibril regularity are investigated and their important roles in determining myofibril force-length relations are explored. The theoretical analysis leads to experimentally verifiable predictions on myofibril force-length relations. For illustration, simulated force-length relations of a myofibril portion consisting of a sarcomere pair are presented.
- Subjects
SKELETAL muscle physiology; SARCOMERES; MYOFIBRILS; ISOCHORIC processes; PREDICTION models
- Publication
Biomechanics & Modeling in Mechanobiology, 2018, Vol 17, Issue 6, p1797
- ISSN
1617-7959
- Publication type
Article
- DOI
10.1007/s10237-018-1057-0