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- Title
A Preorganized Metalloreceptor for Alkaline Earth Ions Showing Calcium Versus Magnesium Selectivity in Water: Biological Activity of Selected Metal Complexes.
- Authors
Amatori, Stefano; Ambrosi, Gianluca; Fanelli, Mirco; Formica, Mauro; Fusi, Vieri; Giorgi, Luca; Macedi, Eleonora; Micheloni, Mauro; Paoli, Paola; Rossi, Patrizia
- Abstract
The N, N′-bis[(3-hydroxy-4-pyron-2-yl)methyl]- N, N′-dimethylethylendiamine (Malten= L) forms the highly stable [CuH−2 L] species in water, in which the converging maltol oxygen atoms form an electron-rich area able to host hard metal ions. When considering the alkaline earth series (AE), the [Cu(H−2 L)] species binds all metal ions, with the exception of Mg2+, exhibiting the relevant property to discriminate Ca2+ versus Mg2+ at physiological pH 7.4; the binding of the AE metal is visible to the naked eye. The stability constant values of the trinuclear [AE{Cu(H−2 L)}2]2+ species formed reach the maximum for Ca2+ (log K=7.7). Ca2+ also forms a tetranuclear [Ca{Cu(H−2 L)}]24+ species at a high Ca2+ concentration. Tri- and tetranuclear calcium complexes show blue- and pink-colored crystals, respectively. [Cu(H−2 L)] is the most active species in inducing DNA alterations. The DNA damages are compatible with its hydrolytic cleavages.
- Subjects
ALKALINE earth metals; LIGHT metals; IONS; PROPERTIES of matter; MAGNESIUM
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 35, p11048
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403084