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- Title
Modified CdS quantum dots as selective turn-on fluorescent nanosensor for detection and determination of methamphetamine.
- Authors
Masteri-Farahani, Majid; Mosleh, Nazanin
- Abstract
Surface modification of cadmium sulfide quantum dots (CdS-QDs) with anti-methamphetamine (anti-METH) antibody produced a new turn-on fluorescent nanosensor, anti-METH-CdS-QDs, for detection of methamphetamine. The anti-METH-CdS-QDs nanosensor was obtained readily via the covalent conjugation of mercaptoacetic acid capped CdS-QDs with anti-METH in the presence of N-ethyl-N′-(3-dimethylaminopropyl carbodiimide) (EDC) and Sulfo-N-hydroxysuccinimide (Sulfo-NHS) as coupling agents. The results of FT-IR and energy dispersive X-ray (EDX) spectroscopies confirmed the functionalization of CdS-QDs with anti-METH species. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses revealed the crystal phase and microstructure of CdS-QDs in the anti-METH-CdS-QDs. The obtained anti-METH-CdS-QDs exhibited fluorescence enhancement upon addition of methamphetamine molecules which allowed the highly sensitive and selective determination of methamphetamine with detection limit of 0.006 mg/L. Further studies disclosed that this nanosensor has little interaction with other drugs such as codeine and ibuprofen. Hence, it can be utilized as simple, inexpensive, and selective nanosensor for determination of methamphetamine in low concentrations.
- Subjects
QUANTUM dot synthesis; QUANTUM dots; METHAMPHETAMINE; THIOGLYCOLIC acid; CADMIUM sulfide; TRANSMISSION electron microscopy; DRUG interactions
- Publication
Journal of Materials Science: Materials in Electronics, 2019, Vol 30, Issue 24, p21170
- ISSN
0957-4522
- Publication type
Article
- DOI
10.1007/s10854-019-02490-8