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- Title
Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis.
- Authors
Hobloss, Samir; Bruguière, Antoine; Pertuit, David; Miyamoto, Tomofumi; Tanaka, Chiaki; Belloir, Christine; Lacaille-Dubois, Marie-Aleth; Briand, Loïc; Mitaine-Offer, Anne-Claire
- Abstract
The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated.
- Subjects
SWEETNESS (Taste); GLYCOSIDES; TASTE receptors; SAPONINS
- Publication
Molecules, 2022, Vol 27, Issue 22, p7866
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27227866