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- Title
An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry.
- Authors
Ibrahim, Tarek S.; Seliem, Israa A.; Panda, Siva S.; Al-Mahmoudy, Amany M. M.; Abdel-Samii, Zakaria K. M.; Alhakamy, Nabil A.; Asfour, Hani Z.; Elagawany, Mohamed; Fulop, Ferenc; Matosiuk, Dariusz
- Abstract
A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.
- Subjects
ACYLATION; BENZOTRIAZOLE; AMINO acid amides; WATER use; CHEMISTRY; AMINO acid synthesis
- Publication
Molecules, 2020, Vol 25, Issue 11, p2501
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25112501