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- Title
Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete.
- Authors
Kwon, Yun; Byun, Woong Sub; Kim, Byung-Yong; Song, Myoung Chong; Bae, Munhyung; Yoon, Yeo Joon; Shin, Jongheon; Lee, Sang Kook; Oh, Dong-Chan
- Abstract
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, <italic>Streptomyces</italic> sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (<bold>1</bold> and <bold>2</bold>), each containing two piperazic acid units and a formyl group at their <italic>N</italic>-terminus. The structures of <bold>1</bold> and <bold>2</bold> were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess d-leucine, d-threonine, d-valine, and <italic>S</italic>-piperazic acid based on the advanced Marfey’s method and a GITC (2,3,4,6-tetra-<italic>O</italic>-acetyl-β-d-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).
- Subjects
ACTINOMYCETALES; GINSENG; STREPTOMYCES; BREAST cancer; THREONINE; LEUCINE
- Publication
Molecules, 2018, Vol 23, Issue 6, p1266
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23061266