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- Title
Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity.
- Authors
Joon Min Cha; Won Se Suh; Tae Hyun Lee; Subedi, Lalita; Sun Yeou Kim; Kang Ro Lee
- Abstract
A new sesquilignan glycoside 1, together with seven known phenolic glycosides 2-8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR) data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY), heteronuclear single-quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear overhauser effect spectroscopy (NOESY)) and HR-FABMS analysis. The anti-inflammatory effects of 1-8 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 μM, respectively.
- Subjects
PHENOLS; GLYCOSIDES; CAPSELLA; ANTI-inflammatory agents; NUCLEAR magnetic resonance
- Publication
Molecules, 2017, Vol 22, Issue 6, p1023
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22061023