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- Title
Synthesis, Crystal Structure, DFT Studies and Evaluation of the Antioxidant Activity of 3,4-Dimethoxybenzenamine Schiff Bases.
- Authors
Aziz, Ahmad Nazif; Taha, Muhammad; Ismail, Nor Hadiani; Anouar, El Hassane; Yousuf, Sammer; Jamil, Waqas; Awang, Khalijah; Ahmat, Norizan; Khan, Khalid M.; Kashif, Syed Muhammad
- Abstract
Schiff bases of 3,4-dimethoxybenzenamine 1-25 were synthesized and evaluated for their antioxidant activity. All the synthesized compounds were characterized by various spectroscopic techniques. In addition, the characterizations of compounds 13, 15 and 16 were supported by crystal X-ray determinations and their geometrical parameters were compared with theoretical DFT calculations at the B3LYP level of theory. Furthermore, the X-ray crystal data of two non-crystalline compounds 8 and 18 were theoretically calculated and compared with the practical values of compounds 13, 15, 16 and found a good agreement. The compounds showed good DPPH scavenging activity ranging from 10.12 to 84.34 μM where compounds 1-4 and 6 showed stronger activity than the standard n-propyl gallate. For the superoxide anion radical assay, compounds 1-3 showed better activity than the standard.
- Subjects
SCHIFF bases; CRYSTAL structure; ANTIOXIDANTS; X-ray absorption; PROPYL gallate
- Publication
Molecules, 2014, Vol 19, Issue 6, p8414
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19068414