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- Title
An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles.
- Authors
Ablajan, Keyume; Kamil, Wetengul; Tuoheti, Anagu; Sun Wan-Fu
- Abstract
A series of novel 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine- 6-carbonitriles were synthesized by a one-pot reaction of 3-amino-1,2,4-triazole, malononitrile and aryl aldehydes in the presence of 20 mol% NaOH in ethanol under heating or ultrasonic irradiation. The structures of the target compounds were confirmed by inspection of their ¹H- NMR, 13C-NMR, IR and MS spectra. The advantages of this method are short reaction times, good yields, high selectivity and operational simplicity.
- Subjects
IRRADIATION; REACTION time; ETHANOL; HETEROCYCLIC compounds; ORGANIC chemistry; PYRIMIDINES
- Publication
Molecules, 2012, Vol 17, Issue 2, p1860
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17021860