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- Title
Synthesis of Methacrylate Monomers with Antibacterial Effects Against S. Mutans.
- Authors
Jingwei He; Söderling, Eva; Österblad, Monica; Vallittu, Pekka K.; Lassila, Lippo V. J.
- Abstract
A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, 1H-NMR, and 13C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.
- Subjects
MONOMERS; ANTIBACTERIAL agents; AMMONIUM compounds; STREPTOCOCCUS mutans; IODIDES
- Publication
Molecules, 2011, Vol 16, Issue 11, p9755
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16119755