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- Title
Myringotomized mice develop myringosclerosis in the pars flaccida and not in the pars tensa.
- Authors
Mattsson, Cecilia; Carlsson, Lena; Marklund, Stefan L.; Hellström, Sten; Mattsson, C; Carlsson, L; Marklund, S L; Hellström, S
- Abstract
The development of myringosclerosis has been correlated with increased production of oxygen-derived free radicals. For the present study, we used a null mutant mouse lacking extracellular superoxide dismutase to test the hypothesis that increased production of free radicals can cause the development of myringosclerosis. Null mutant mice and wild-type, control mice were myringotomized and kept in ambient air for 3 weeks. Both groups developed myringosclerosis in the pars flaccida, but not in the pars tensa. The sclerotic lesions were visible in both the light and the electron microscope but not in the otomicroscope. In particular, the localization of the sclerotic deposits was found beneath both the inner and outer epidermal epithelium. No difference concerning the extent or number of sclerotic lesions between the null mutant and the wild-type mice could be distinguished.
- Publication
Laryngoscope, 1997, Vol 107, Issue 2, p200
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1097/00005537-199702000-00011