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- Title
DNIC is a Structure Providing Specificity of Physiological Effects of NO.
- Authors
Titov, V. Yu.; Dolgorukova, A. M.; Osipov, A. N.; Kochish, I. I.
- Abstract
Metabolism of nitric oxide (NO) donors: dinitrosyl iron complexes (DNIC), nitrosothiols (RSNO), and nitroprusside was studied on a chick embryo model. The obtained results give reason to assume that DNIC constituting the main pool of nitroso compounds in the vast majority of tissues are NO donors immediately interacting with the physiological target of NO, and other NO donors can perform this function after their transformation into DNIC. NO is released from DNIC not spontaneously, but under a joint influence of a factor destroying the complex and a target having chemical affinity for NO. A similar mechanism is apparently implicated in NO passage through the cell membrane.
- Subjects
CHICKEN embryos; CHEMICAL affinity; NITROSO compounds; IRON; SODIUM nitroferricyanide; CHICKS
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 176, Issue 2, p160
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-05987-3