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- Title
Chemical Profile and Antioxidant and Tyrosinase Inhibitory Activity of Chamaemelum nobile L. Green Extracts.
- Authors
Polcaro, Luciana Maria; Cerulli, Antonietta; Montella, Francesco; Ciaglia, Elena; Masullo, Milena; Piacente, Sonia
- Abstract
The request for skin-whitening agents and bioactive principles able to control hyperpigmentation disorders is continuously growing. Chamomile (Matricaria chamomilla) is used as a remedy for skin diseases, but little is known about the ability of Roman chamomile (Chamaemelum nobile) to act as a skin-whitening agent. With the aim to investigate antioxidant and lightening potential, fresh aerial parts of C. nobile were extracted by maceration, ultrasound-assisted extraction, and solid–liquid dynamic (SLDE-Naviglio) extraction using EtOH/H2O mixtures. Moreover, 32 metabolites (flavonoids, sesquiterpenoids, amides, and polar fatty acids) were identified by liquid chromatography/mass spectrometry. Principal component analysis revealed how the extract EtOH/H2O 50% (Naviglio and long maceration), along with the extract EtOH/H2O 60% (maceration) were richest in flavonoids. All extracts were tested by TEAC and DPPH assays, and to determine their in vitro antioxidant activity, the DHR 123 probe–intracellular ROS assay in HaCaT cells, for some extracts, was performed. Moreover, their ability to exert a whitening effect was tested by analyzing their tyrosinase inhibitory activity. The quantitative determination of apigenin, known as a natural tyrosinase inhibitor, was performed by LC-ESI/QTrap/MS/MS using the multiple reaction monitoring (MRM) method. These results are promising for selecting an extraction method to obtain a sustainable product rich in bioactives.
- Subjects
ANTIOXIDANTS; PHENOL oxidase; ROMAN chamomile; PLANT extracts; COSMETICS; SKIN care
- Publication
Cosmetics (2079-9284), 2024, Vol 11, Issue 3, p94
- ISSN
2079-9284
- Publication type
Article
- DOI
10.3390/cosmetics11030094