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- Title
Intercellular adhesion molecule-1: a protective haplotype against multiple sclerosis.
- Authors
Cournu-Rebeix, I.; Génin, E.; Lesca, G.; Azoulay-Cayla, A.; Tubridy, N.; Noé, E.; Clanet, M.; Edan, G.; Clerget-Darpoux, F.; Sémana, C.; Fontaine, B.
- Abstract
Intercellular adhesion molecule-1 (ICAM-1) and its receptors are adhesion molecules that play a key role in the transmigration of inflammatory cells through the blood-brain barrier, one of the earliest events in multiple sclerosis (MS), which leads to demyelination in the central nervous system. To investigate the role of genes encoding ICAM-1 and its receptors, we used a strategy of genetic linkage and association in 439 case-parent MS families of French origin, well characterized according to HLA status and severity. We demonstrate that the genes encoding ICAM-1 receptors do not influence MS susceptibility or severity. ICAM-1 had a modest, but significant effect on MS genetic susceptibility, independent of HLA and disease severity. We observed a rare, and an as yet unreported, ICAM-1 gene haplotype defined by amino acids K469 and R241 that was never transmitted to patients suggesting a protective effect against MS in our population.Genes and Immunity (2003) 4, 518-523. doi:10.1038/sj.gene.6364009
- Subjects
CELL adhesion molecules; MULTIPLE sclerosis; DEMYELINATION; CENTRAL nervous system; GENETICS
- Publication
Genes & Immunity, 2003, Vol 4, Issue 7, p518
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364009