We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study.
- Authors
Zeydan, Burcu; Deelchand, Dinesh K.; Tosakulwong, Nirubol; Lesnick, Timothy G.; Kantarci, Orhun H.; Machulda, Mary M.; Knopman, David S.; Lowe, Val J.; Jack, Clifford R.; Petersen, Ronald C.; Öz, Gülin; Kantarci, Kejal; Jack, Clifford R Jr; Öz, Gülin
- Abstract
<bold>Background and Purpose: </bold>Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy (1 H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment.<bold>Methods: </bold>Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel 1 H-MRS study that examined metabolite changes in the posterior cingulate gyri. To be included, controls had to have low β-amyloid load on [11 C] Pittsburgh Compound B (PiB)-PET (standard uptake value ratio; SUVr < 1.42) and patients with amnestic mild cognitive impairment had to have high β-amyloid load (SUVr ≥ 1.42).<bold>Results: </bold>Glutamate concentration and the glutamate/myo-inositol ratio were lower in patients with amnestic mild cognitive impairment than clinically normal controls (P < .05). Higher global cortical PiB-PET SUVr correlated with lower glutamate/myo-inositol (r = -.3, P = .04).<bold>Conclusions: </bold>The advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1 H-MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.
- Subjects
MILD cognitive impairment; MAGNETIC resonance imaging; NEURODEGENERATION; SPECTRUM analysis; GLUTAMIC acid
- Publication
Journal of Neuroimaging, 2017, Vol 27, Issue 6, p630
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12454