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- Title
Correction for Susceptibility Distortions Increases the Performance of Arterial Spin Labeling in Patients with Cerebrovascular Disease.
- Authors
Madai, Vince I.; Martin, Steve Z.; Samson‐Himmelstjerna, Federico C.; Herzig, Cornelius X.; Mutke, Matthias A.; Wood, Carla N.; Thamm, Thoralf; Zweynert, Sarah; Bauer, Miriam; Hetzer, Stefan; Günther, Matthias; Sobesky, Jan
- Abstract
<bold>Background and Purpose: </bold>Arterial spin labeling (ASL) is an MRI technique to measure cerebral blood flow (CBF) without the need of exogenous contrast agents and is thus a promising alternative to the clinical standard dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion imaging. Latest international guidelines encourage its application in the clinical setting. However, susceptibility-induced image distortions impair ASL with fast readout modules (eg Echo Planar Imaging, EPI; gradient and spin echo, GRASE). In the present study, we investigated the benefit of a distortion correction for ASL compared to DSC.<bold>Methods: </bold>A pulsed ASL (PASL) sequence combined with a 3D-GRASE readout at multiple inflow times (multi-TI) was used and was corrected for susceptibility distortions using a FMRIB Software Library (FSL) implemented tool TOPUP. We performed qualitative (three expert raters) and quantitative (volume of interest [VOI]-based) comparisons of ASL and DSC imaging in 13 patients with chronic steno-occlusive disease.<bold>Results: </bold>In the qualitative analysis, distortion correction of the images led to a strong increase in diagnostic precision of ASL compared to DSC in the anterior cerebral artery (ACA) perfusion territory, where the susceptibility artifact was most pronounced (specificity 8% vs. 75%). In the quantitative analysis, the correlation between ASL and DSC values increased for all perfusion territories with the best improvement for the ACA territory (for anterior, middle and posterior cerebral artery: ACA: rho -0.22 vs. 0.71; MCA: rho 0.58 vs. 0.76; PCA: rho 0.58 vs. 0.63).<bold>Conclusions: </bold>We showed that susceptibility distortion correction strongly improves the comparability of multi-TI ASL 3D-GRASE to DSC in steno-occlusive disease. We suggest it to be implemented in ASL postprocessing routines.
- Subjects
SPIN labels; IMAGING of cerebral circulation; CEREBROVASCULAR disease patients; CONTRAST-enhanced magnetic resonance imaging; ANTERIOR cerebral artery; CEREBRAL circulation; COMPARATIVE studies; DIAGNOSTIC imaging; FREE radicals; INFARCTION; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; NUCLEAR magnetic resonance spectroscopy; RESEARCH; TRANSCRANIAL Doppler ultrasonography; EVALUATION research; CAROTID artery stenosis; MEDICAL artifacts; MAGNETIC resonance angiography
- Publication
Journal of Neuroimaging, 2016, Vol 26, Issue 4, p436
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12331