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- Title
From Gut to Brain: Bioencapsulated Therapeutic Protein Reduces Amyloid Load Upon Oral Delivery.
- Authors
Mäger, Imre; Roberts, Thomas C; Wood, Matthew JA; EL Andaloussi, Samir
- Abstract
The authors discuss a study by N. Kohli and colleagues regarding the potential of bioencapsulated therapeutic proteins in reducing Alzheimer's disease (AD)-related amyloid load in the brain and retina upon oral delivery. Topics include the use of exosomes in demonstrating systemic delivery of short interfering RNAs to the brain, the proposed use of bioencapsulation of cargoes, and the oral administration of cholera toxin B subunit-myelin basic protein (CBP-MBP).
- Subjects
THERAPEUTIC use of proteins; ALZHEIMER'S disease treatment; AMYLOID; EXOSOMES; ENCAPSULATION (Catalysis); CHOLERA toxin; MYELIN basic protein
- Publication
Molecular Therapy, 2014, Vol 22, Issue 3, p485
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1038/mt.2014.13