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- Title
Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit.
- Authors
Nakajima, Hiroyuki; Nishida, Eisuke; Yonemura, Shigenobu; Murata, Masayuki; Nakamura, Nobuhiro; Piwnica-Worms, Helen
- Abstract
Myt1 was originally identified as an inhibitory kinase for Cdc2 (Cdk1), the master engine of mitosis, and has been thought to function, together with Wee1, as a negative regulator of mitotic entry. In this study, we report an unexpected finding that Myt1 is essential for Golgi and endoplasmic reticulum (ER) assembly during telophase in mammalian cells. Our analyses reveal that both cyclin B1 and cyclin B2 serve as targets of Myt1 for proper Golgi and ER assembly to occur. Thus, our results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis.
- Subjects
PROTEIN kinases; MITOSIS; ENDOPLASMIC reticulum; CELLS; MAMMALS
- Publication
Journal of Cell Biology, 2008, Vol 181, Issue 1, p89
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200708176