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- Title
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson crom claudin-1 9-deficient mice.
- Authors
Miyamofo, Tatsuo; Morita, Kazumasa; Takemoto, Daisuke; Takeuchi, Kosei; Kitano, Yuka; Miyakawa, Tsuyoshi; Nakayama, Kiyomi; Okamura, Yasushi; Sasaki, Hiroyuki; Miyachi, Yoshiki; Furuse, Mikio; Tsukita, Shoichiro
- Abstract
Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-1 9, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. Electrophysiologiccil analyses showed that the claudin-19 deficiency affected the nerve conduction of peripheral myelinated fibers. Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based Tis, and they have also suggested that these us are not involved in the polarized morphogenesis but are involved in the electrophysiological "sealing" function of Schwann cells.
- Subjects
TIGHT junctions; AXONS; CELL adhesion molecules; EPITHELIAL cells; PERIPHERAL nervous system; MORPHOLOGY
- Publication
Journal of Cell Biology, 2005, Vol 169, Issue 3, p527
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200501154