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- Title
HEPATOPROTECTIVE AND ANTIOXIDANT POTENTIAL OF Cichorium intybus L. AND Lentinus edodes Berk. IN ANIMAL MODELS.
- Authors
BUKHARI, S. A.; FAROOQ, M.; ANWAR, H.; SULIMAN, M.; AWAN, M. Q.; ZIA-UL-HAQ, M.; RIAZ, M.; MOGA, M.; FESTILA, D. G.
- Abstract
Cichorium intybus L. and Lentinus edodes Berk. are used by indigenous communities in Pakistan to cure liver disorders. The current study has been designed to explore synergistic ameloriative effects of Cichorium intybus L. and Lentinus edodes Berk. in hepatoinjuries and to co-relate it with antioxidant potential. Albino rats were subdivided into control group treated with normal chick diet; induced group treated with carbon tetrachloride (CCl4) and experimental groups treated with extracts. Blood samples were analysed at 1st, 3rd, and 6th week and data were statistically analysed. Administration of CCl4 significantly (p < 0.05) increased liver enzymes like, aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), and there was a significant (p < 0.05) deterioration in serum total protein (TP) and serum electrolytes epically sodium (Na+), chloride (Cl-) and potassium (K+). Histopathological studies confirmed the results of biochemical analysis thus confirming therapeutic efficacy of Cichorium intybus L. and Lentinus edodes Berk. extracts. These outcomes propose that Cichorium intybus L. and Lentinus edodes Berk. extracts have a significant hepato-protective potential in liver damages caused by chemicals like CCl4.
- Subjects
CHICORY; SHIITAKE; LIVER injuries; THERAPEUTICS; ANTIOXIDANTS; ALANINE aminotransferase; LIVER enzymes; THERAPEUTIC use of plant extracts; ANIMAL models in research
- Publication
Oxidation Communications, 2016, Vol 39, Issue 3-I, p2313
- ISSN
0209-4541
- Publication type
Article