We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity.
- Authors
Drouet, Maryline; Cuvelier, Elodie; Chai, Feng; Genay, Stéphanie; Odou, Pascal; Décaudin, Bertrand
- Abstract
Background: Phlebitis is a common side effect of vancomycin peripheral intravenous (PIV) infusion. As only one PIV catheter is frequently used to deliver several drugs to hospitalized patients through the same Y-site, perturbation of the infusion flow by hydration or other IV medication may influence vancomycin exposure to endothelial cells and modulate toxicity. Methods: We assessed the toxicity of variations in vancomycin concentration induced by drug mass flow variations in human umbilical vein endothelial cells (HUVECs), simulating a 24 h multi-infusion therapy on the same line. Results were expressed as the percentage of viable cells compared with a 100% control, and the Kruskal–Wallis test was used to assess the toxicity of vancomycin. Results: Our results showed that variations in vancomycin concentration did not significantly influence local toxicity compared to a fixed concentration of vancomycin. Nevertheless, the loss of cell viability induced by mechanical trauma mimicking multidrug infusion could increase the risk of phlebitis. Conclusion: To ensure that vancomycin-induced phlebitis must have other causes than variation in drug mass flow, further in vitro experiments should be performed to limit mechanical stress to frequent culture medium change.
- Subjects
ENDOTHELIAL cells; VANCOMYCIN; UMBILICAL veins; STRAINS &; stresses (Mechanics); KRUSKAL-Wallis Test
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 1, p16
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11010016