We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission.
- Authors
Li, Nancy Yanzhe; Poh, Gang Quan; Teng, Gladys Chung Wei; Chen, Hui Hiong; Chan, Douglas Su Gin; Chan, Siew-Pang; Tambyah, Paul Anantharajah; Bagdasarian, Natasha; Wu, Jia En
- Abstract
Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of this study were to determine the incidence and susceptibility of uropathogens upon hospital admission and to develop a risk-scoring model to predict the presence of ceftriaxone-resistance uropathogens (CrP). This was a retrospective observational cohort study of patients with a positive urine culture within 48 h of presentation at National University Hospital, Singapore between June 2015 and August 2015. Escherichia coli was the most common uropathogen isolated (51.7%), followed by Klebsiella pneumonia (15.1%) and Pseudomonas aeruginosa (8.2%). Overall, 372 out of 869 isolates (42.8%) were resistant to ceftriaxone. Hospitalization for ≥2 days within past 30 days, antibiotic use within the past 3 months and male gender were associated with the presence of CrP. A risk score based on these parameters successfully predicted CrP with an area under the curve of 0.68. The risk score will help clinicians to accurately predict antibiotic resistance at the individual patient level and allow physicians to safely prescribe empiric ceftriaxone in patients at low risk of CrP, thus reducing the antibiotic selection pressure that is driving carbapenem resistance in hospitals throughout Asia.
- Subjects
HOSPITAL admission &; discharge; DRUG resistance in bacteria; DRUG resistance in microorganisms; FORECASTING; KLEBSIELLA pneumoniae; SHIGELLOSIS
- Publication
Antibiotics (2079-6382), 2020, Vol 9, Issue 6, p316
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics9060316