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- Title
维生素D受体检测方法的研究进展.
- Authors
李游山; 祁珊珊; 王永吉
- Abstract
The major biological function of vitamin D is to regulate the metabolism of calcium and phosphate, and to modulate immune activity and cellular proliferation and differentiation. It is believed that vitamin D acts through binding to its nuclear receptor, vitamin D receptor (VDR). Therefore, the receptor is a determinant for a cell to respond to the vitamin D. The tissues containing high levels of VDR, such as intestine, kidney, bone and parathyroid, are known as the main targets of vitamin D. In the past 4 decades, several assays have been established for determining VDR in various tissues. However, the application of these methods also results in controversial results perhaps due to the varied specificity of each assay. We have recently established highly specific and sensitive immunoassays, which have been successfully used to determine VDR in the selected tissues. In this review, we discuss advantages and limitations of each assay and point out that the assay selection may be a key for the success in finding the receptor in target tissues.
- Publication
Chinese Journal of Osteoporosis, 2015, Vol 21, Issue 11, p1402
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2015.11.024