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- Title
Attenuation of Formalin-Induced Inflammatory Nociception by Propentofylline: Modulation of Glia.
- Authors
Sun, M.-L.; Yu, H.-X.; Tian, J.; Yu, Y.-Q.
- Abstract
We examined the effects of propentofylline (PPF) injected intracerebroventricularly (i.c.v., 30 mM, 10 μl) into female Sprague-Dawley rats on pain responses in the formalin test and on the number of glial fibrillary acidic protein-immunopositive (GFAP-ip) astrocytes in the caudatoputamen (CPu) and periaqueductal grey (PAG) of these animals. The mean durations of flinch and lifting/biting of the limb in the PPF group vs. the vehicle (normal saline) group within phase 1 of the pain response were 280.0 ± ± 71.6 vs. 401.0 ± 69.0 sec and 69.5 ± 34.8 vs. 145.5 ± 18.6 sec, respectively ( P > 0.05 in both cases, n = 7). During phase 2, the respective figures were 152.6 ± 104.0 vs. 1602.7 ± 100.9 sec and 79.1 ± ± 69.1 vs. 376.1 ± 56.5 sec ( P < 0.01 in both cases). The mean numbers of GFAP-positive astrocytes per slice observed in the PPF and vehicle groups in the CPu were 35 ± 3.1 vs. 55 ± 1.9 ( P < 0.01, n = 7), and those in the PAG were 30 ± 2.2 vs. 49 ± 1.2 ( P < 0.01, n = 11). Thus, i. c.v. administration of PPF suppresses inflammatory pain induced by formalin injection in rats; there are reasons to believe that glial cells (astrocytes) in certain brain structures are intensely involved in the formation of a sensation of inflammatory pain.
- Subjects
ASTROCYTES; FORMALDEHYDE; NEUROGLIA; SPRAGUE Dawley rats; MURIDAE
- Publication
Neurophysiology, 2012, Vol 44, Issue 6, p441
- ISSN
0090-2977
- Publication type
Article
- DOI
10.1007/s11062-012-9315-8