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- Title
Timing Is Everything. The Importance of Alignment of Time Anchors for Observational Causal Inference Research.
- Authors
Taylor, Stephanie Parks; Kowalkowski, Marc A.; Admon, Andrew J.
- Abstract
The article discusses that randomized controlled trials are the gold-standard approach for evaluation of the risks, benefits, and comparative effectiveness of critical care interventions but it is scarce in many intensive care therapies. The challenges includes time-sensitive eligibility windows, the complexity of interventions and real or perceived ethical concerns over withholding lifesaving therapy from critically ill patients.
- Subjects
RANDOMIZED controlled trials; CRITICAL care medicine; LIFESAVING; CRITICALLY ill; DRUG efficacy; RESEARCH funding
- Publication
Annals of the American Thoracic Society, 2021, Vol 18, Issue 5, p769
- ISSN
2329-6933
- Publication type
journal article
- DOI
10.1513/AnnalsATS.202009-1163VP