We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence.
- Authors
Tan, Dong‐Hang; Zeng, Yao‐Fu; Liu, Yao; Lv, Wen‐Xin; Li, Qingjiang; Wang, Honggen
- Abstract
Abstract: The prenyl group is an important component in bioactive compounds. Herein, we report the assembly of prenylated heteroarenes through a cascade Minisci reaction and acid‐promoted dehydration sequence. The use of potassium (3‐hydroxy‐3‐methylbut‐1‐yl)trifluoroborate as a new coupling reagent allows the direct introduction of prenyl and 3‐hydroxy‐3‐methylbutyl groups to a wide variety of electron‐deficient heteroarenes. Synthetic application is also demonstrated.
- Subjects
HETEROARENES; ISOPRENYLATION; BIOACTIVE compounds; DEHYDRATION reactions; CHEMICAL synthesis; THERAPEUTICS
- Publication
ChemistryOpen, 2016, Vol 5, Issue 6, p535
- ISSN
2191-1363
- Publication type
Article
- DOI
10.1002/open.201600096