We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
There is a world beyond protein mutations: the role of non-coding RNAs in melanomagenesis.
- Authors
Swoboda, Rolf K.; Herlyn, Meenhard
- Abstract
Until recently, the general perception has been that mutations in protein-coding genes are responsible for tumorigenesis. With the discovery of V600E BRAF in about 50% of cutaneous melanomas, there was an increased effort to find additional mutations. However, mutations characterized in melanoma to date cannot account for the development of all melanomas. With the discovery of micro RNAs as important players in melanomagenesis, protein mutations are no longer considered the sole drivers of tumors. Recent research findings have expanded the view for tumor initiation and progression to additional non-coding RNAs. The data suggest that tumorigenesis is likely an interplay between mutated proteins and deregulation of non-coding RNAs in the cell with an additional role of the tumor environment. With the exception of micro RNAs, our knowledge of the role of non-coding RNAs in melanoma is in its infancy. Using few examples, we will summarize some of the roles of non-coding RNAs in tumorigenesis. Thus, there is a whole world beyond protein-coding sequences and micro RNAs, which can cause melanoma.
- Subjects
CHEMICAL modification of proteins; NEUROENDOCRINE tumors; MELANOGENESIS; CARCINOGENESIS; GENETIC mutation
- Publication
Experimental Dermatology, 2013, Vol 22, Issue 5, p303
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12117