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Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 4, p. 1, doi. 10.1371/journal.pntd.0000651
By:
- Chen, Chiung-Kuang;
- Leung, Siegfried S. F.;
- Guilbert, Christophe;
- Jacobson, Matthew P.;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole.
Published in:
PLoS Neglected Tropical Diseases, 2010, v. 4, n. 4, p. 1, doi. 10.1371/journal.pntd.0000651
By:
- Chiung-Kuang Chen;
- Leung, Siegfried S. F.;
- Guilbert, Christophe;
- Jacobson, Matthew P.;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
Correction: The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.
Published in:
2016
By:
- Ziniel, Peter D.;
- Karumudi, Bhargava;
- Barnard, Andrew H.;
- Fisher, Ethan M. S.;
- Thatcher, Gregory R. J.;
- Podust, Larissa M.;
- Williams, David L.
Publication type:
Correction Notice
The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 12, p. 1, doi. 10.1371/journal.pntd.0004279
By:
- Ziniel, Peter D.;
- Karumudi, Bhargava;
- Barnard, Andrew H.;
- Fisher, Ethan M. S.;
- Thatcher, Gregory R. J.;
- Podust, Larissa M.;
- Williams, David L.
Publication type:
Article
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003588
By:
- McCall, Laura-Isobel;
- El Aroussi, Amale;
- Choi, Jun Yong;
- Vieira, Debora F.;
- De Muylder, Geraldine;
- Johnston, Jonathan B.;
- Chen, Steven;
- Kellar, Danielle;
- Siqueira-Neto, Jair L.;
- Roush, William R.;
- Podust, Larissa M.;
- McKerrow, James H.
Publication type:
Article
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase.
Published in:
PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003588
By:
- McCall, Laura-Isobel;
- El Aroussi, Amale;
- Choi, Jun Yong;
- Vieira, Debora F.;
- De Muylder, Geraldine;
- Johnston, Jonathan B.;
- Chen, Steven;
- Kellar, Danielle;
- Siqueira-Neto, Jair L.;
- Roush, William R.;
- Podust, Larissa M.;
- McKerrow, James H.
Publication type:
Article
Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.
Published in:
Molecular Microbiology, 2010, v. 77, n. 3, p. 730, doi. 10.1111/j.1365-2958.2010.07243.x
By:
- Ouellet, Hugues;
- Guan, Shenheng;
- Johnston, Jonathan B.;
- Chow, Eric D.;
- Kells, Petrea M.;
- Burlingame, Alma L.;
- Cox, Jeffery S.;
- Podust, Larissa M.;
- Ortiz De Montellano, Paul R.
Publication type:
Article
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Published in:
PLoS Neglected Tropical Diseases, 2017, v. 11, n. 12, p. 1, doi. 10.1371/journal.pntd.0006132
By:
- Calvet, Claudia Magalhaes;
- Choi, Jun Yong;
- Thomas, Diane;
- Suzuki, Brian;
- Hirata, Ken;
- Lostracco-Johnson, Sharon;
- de Mesquita, Liliane Batista;
- Nogueira, Alanderson;
- Meuser-Batista, Marcelo;
- Silva, Tatiana Araujo;
- Siqueira-Neto, Jair Lage;
- Roush, William R.;
- de Souza Pereira, Mirian Claudia;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).
Published in:
PLoS Neglected Tropical Diseases, 2017, v. 11, n. 12, p. 1, doi. 10.1371/journal.pntd.0006104
By:
- Debnath, Anjan;
- Jennings, Gareth;
- Aksenov, Alexander;
- Luth, Madeline R.;
- Abagyan, Ruben;
- McKerrow, James H.;
- Podust, Larissa M.;
- Calvet, Claudia M.;
- Zhou, Wenxu;
- Nes, W. David
Publication type:
Article
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.
Published in:
PLoS Pathogens, 2018, v. 14, n. 9, p. 1, doi. 10.1371/journal.ppat.1007245
By:
- Zhou, Wenxu;
- Vanderloop, Boden H.;
- Nes, W. David;
- Debnath, Anjan;
- Jennings, Gareth;
- Hahn, Hye Jee;
- Podust, Larissa M.;
- Chaudhuri, Minu
Publication type:
Article
Expanding the Binding Envelope of CYP51 Inhibitors Targeting Trypanosoma cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives.
Published in:
ChemBioChem, 2014, v. 15, n. 8, p. 1111, doi. 10.1002/cbic.201402027
By:
- Vieira, Debora F.;
- Choi, Jun Yong;
- Roush, William R.;
- Podust, Larissa M.
Publication type:
Article
A highly conserved mycobacterial cholesterol catabolic pathway.
Published in:
Environmental Microbiology, 2013, v. 15, n. 8, p. 2342, doi. 10.1111/1462-2920.12108
By:
- García ‐ Fernández, Esther;
- Frank, Daniel J.;
- Galán, Beatriz;
- Kells, Petrea M.;
- Podust, Larissa M.;
- García, José L.;
- Ortiz de Montellano, Paul R.
Publication type:
Article
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51.
Published in:
PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001736
By:
- Gunatilleke, Shamila S.;
- Calvet, Claudia M.;
- Johnston, Jonathan B.;
- Chen, Chiung-Kuang;
- Erenburg, Grigori;
- Gut, Jiri;
- Engel, Juan C.;
- Ang, Kenny K. H.;
- Mulvaney, Joseph;
- Chen, Steven;
- Arkin, Michelle R.;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51.
Published in:
PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001736
By:
- Gunatilleke, Shamila S.;
- Calvet, Claudia M.;
- Johnston, Jonathan B.;
- Chen, Chiung-Kuang;
- Erenburg, Grigori;
- Gut, Jiri;
- Engel, Juan C.;
- Ang, Kenny K. H.;
- Mulvaney, Joseph;
- Chen, Steven;
- Arkin, Michelle R.;
- McKerrow, James H.;
- Podust, Larissa M.
Publication type:
Article
Giardia fatty acyl-CoA synthetases as potential drug targets.
Published in:
Frontiers in Microbiology, 2015, p. 1, doi. 10.3389/fmicb.2015.00753
By:
- Fengguang Guo;
- Ortega-Pierres, Guadalupe;
- Argüello-García, Raúl;
- Haili Zhang;
- Guan Zhu;
- Sriramulu, Dinesh;
- Podust, Larissa M.
Publication type:
Article
Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations.
Published in:
Nature Chemistry, 2015, v. 7, n. 8, p. 653, doi. 10.1038/nchem.2285
By:
- Narayan, Alison R. H.;
- Jiménez-Osés, Gonzalo;
- Liu, Peng;
- Negretti, Solymar;
- Zhao, Wanxiang;
- Gilbert, Michael M.;
- Ramabhadran, Raghunath O.;
- Yang, Yun-Fang;
- Furan, Lawrence R.;
- Li, Zhe;
- Podust, Larissa M.;
- Montgomery, John;
- Houk, K. N.;
- Sherman, David H.
Publication type:
Article
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.
Published in:
Nature Chemistry, 2011, v. 3, n. 8, p. 628, doi. 10.1038/nchem.1087
By:
- Carlson, Jacob C.;
- Li, Shengying;
- Gunatilleke, Shamila S.;
- Anzai, Yojiro;
- Burr, Douglas A.;
- Podust, Larissa M.;
- Sherman, David H.
Publication type:
Article
Comparison of the 1.85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways.
Published in:
Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 1, p. 255, doi. 10.1110/ps.03384804
By:
- Podust, Larissa M.;
- Bach, Horacio;
- Kim, Youngchang;
- Lamb, David C.;
- Arase, Miharu;
- Sherman, David H.;
- Kelly, Steven L.;
- Waterman, Michael R.
Publication type:
Article

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