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- Title
Effects of high-sodium intake on systemic blood pressure and vascular responses in spontaneously diabetic WBN/Kob- Lepr<sup> fa/fa</sup> rats.
- Authors
Takagi, Yoshiichi; Kadowaki, Haruno; Kobayashi, Ikumi; Ito, Kaoru; Ito, Katsuaki; Shirai, Mitsuyuki; Asai, Fumitoshi
- Abstract
The prevalence of type 2 diabetes mellitus (T2 DM) and hypertension has markedly increased worldwide. The purpose of the present study was to examine the effects of a high-salt intake on the systolic blood pressure ( SBP) and vascular responses in WBN/Kob- Lepr fa/fa ( WBKDF) rats, a new spontaneous animal model of T2 DM. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium ( NS, 0.26%) diet or high-sodium ( HS, 8%) diet for 14 weeks: (i) Wistar rats on NS diet (Wistar- NS); (ii) Wistar rats on HS diet (Wistar- HS); (iii) WBKDF rats on NS diet ( WBKDF- NS); (iv) WBKDF rats on HS diets ( WBKDF- HS). Neither WBKDF- NS nor Wistar- NS rats showed significant changes in SBP throughout the experiment, but both WBKDF- HS and Wistar- HS exhibited significant elevation of SBP, which was more prominent ( P<.01) in WBKDF- HS than in Wistar- HS. Phenylephrine-induced contractions of isolated thoracic aortic rings were significantly ( P<.01) enhanced in WBKDF- HS and Wistar- HS compared with the respective strain of rats on the NS diet. In contrast, acetylcholine- and nitroprusside-induced relaxation were significantly ( P<.01) diminished in both WBKDF- HS and Wistar- HS, and these HS diet-induced changes were more profound ( P<.01) in WBKDF rats than in Wistar rats. Significantly ( P<.05) higher plasma concentrations of 8-iso-prostaglandin F2α and sodium ions were observed in WBKDF- HS than in Wistar- HS. The current study demonstrated that WBKDF- HS rats developed salt-sensitive hypertension associated with vascular dysfunction. The WBKDF rat may be a useful model for investigating the etiology of hypertension with T2 DM.
- Subjects
HIGH-salt diet; HYPERTENSION; TYPE 2 diabetes; PEOPLE with diabetes; LABORATORY rats; DISEASE risk factors
- Publication
Clinical & Experimental Pharmacology & Physiology, 2017, Vol 44, Issue 2, p305
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/1440-1681.12700