We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population.
- Authors
Iwasaki, Naoko; Horikawa, Yukio; Tsuchiya, Takafumi; Kitamura, Yutaka; Nakamura, Takahiro; Tanizawa, Yukio; Oka, Yoshitomo; Hara, Kazuo; Kadowaki, Takashi; Awata, Takuya; Honda, Masashi; Yamashita, Katsuko; Oda, Naohisa; Yu, Li; Yamada, Norihiro; Ogata, Makiko; Kamatani, Naoyuki; Iwamoto, Yasuhiko; Bosque-Plata, Laura Del; Hayes, M. Geoffrey
- Abstract
Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53,P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and =50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis =50 years OR=0.82 and 0.80, respectively;P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.
- Subjects
GENETICS of diabetes; CALPAIN; PROTEOLYTIC enzymes; TYPE 2 diabetes; GENETIC polymorphisms; STANDARD deviations; MEDICAL genetics
- Publication
Journal of Human Genetics, 2005, Vol 50, Issue 2, p92
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-004-0225-5