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- Title
Neutralizing Antibodies against Enteroviruses in Patients with Hand, Foot and Mouth Disease.
- Authors
Lam Anh Nguyet; Tran Tan Thanh; Le Nguyen Thanh Nhan; Nguyen Thi Thu Hong; Le Nguyen Truc Nhu; Hoang Minh Tu Van; Nguyen Thi Han Ny; Nguyen To Anh; Do Duong Kim Han; Ha Manh Tuan; Vu Quang Huy; Ho Lu Viet; Hoang Quoc Cuong; Nguyen Thi Thanh Thao; Do Chau Viet; Truong Huu Khanh; Louise Thwaites; Hannah Clapham; Nguyen Thanh Hung; Nguyen Van Vinh Chau
- Abstract
Hand, foot and mouth disease (HFMD) is an emerging infection with pandemic potential. Knowledge of neutralizing antibody responses among its pathogens is essential to inform vaccine development and epidemiologic research. We used 120 paired-plasma samples collected at enrollment and >7 days after the onset of illness from HFMD patients infected with enterovirus A71 (EV-A71), coxsackievirus A (CVA) 6, CVA10, and CVA16 to study cross neutralization. For homotypic viruses, seropositivity increased from <60% at enrollment to 97%-100% at follow-up, corresponding to seroconversion rates of 57%-93%. Seroconversion for heterotypic viruses was recorded in only 3%-23% of patients. All plasma samples from patients infected with EV-A71 subgenogroup B5 could neutralize the emerging EV-A71 subgenogroup C4. Collectively, our results support previous reports about the potential benefit of EV-A71 vaccine but highlight the necessity of multivalent vaccines to control HFMD.
- Subjects
VIETNAM; FOOT &; mouth disease; HAND, foot &; mouth disease; ENTEROVIRUSES; EMERGING infectious diseases; RESEARCH; IMMUNOGLOBULINS; VIRAL vaccines; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RESEARCH funding
- Publication
Emerging Infectious Diseases, 2020, Vol 26, Issue 2, p398
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2602.190721