We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014-2015.
- Authors
Dong-Hun Lee; Torchetti, Mia Kim; Hicks, Joseph; Killian, Mary Lea; Bahl, Justin; Pantin-Jackwood, Mary; Swayne, David E.; Lee, Dong-Hun
- Abstract
Eurasia highly pathogenic avian influenza virus (HPAIV) H5 clade 2.3.4.4 emerged in North America at the end of 2014 and caused outbreaks affecting >50 million poultry in the United States before eradication in June 2015. We investigated the underlying ecologic and epidemiologic processes associated with this viral spread by performing a comparative genomic study using 268 full-length genome sequences and data from outbreak investigations. Reassortant HPAIV H5N2 circulated in wild birds along the Pacific flyway before several spillover events transmitting the virus to poultry farms. Our analysis suggests that >3 separate introductions of HPAIV H5N2 into Midwest states occurred during March-June 2015; transmission to Midwest poultry farms from Pacific wild birds occurred ≈1.7-2.4 months before detection. Once established in poultry, the virus rapidly spread between turkey and chicken farms in neighboring states. Enhanced biosecurity is required to prevent the introduction and dissemination of HPAIV across the poultry industry.
- Subjects
NORTH America; AVIAN influenza; H5N1 Influenza; VIRUS diseases in poultry; INFLUENZA viruses; BIRDS as carriers of disease; AVIAN influenza epidemiology; ANIMALS; EPIDEMICS; BIOLOGICAL evolution; GENOMES; HISTORY; POULTRY; PROBABILITY theory; RESEARCH funding; RNA; VIRUSES; INFLUENZA A virus; INFECTIOUS disease transmission
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 10, p1840
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2410.171891