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- Title
Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.
- Authors
Beasley, David W. C.; Davis, C. Todd; Estrada-Franco, Jose; Navarro-Lopez, Roberto; Campomanes-Cortes, Arturo; Tesh, Robert B.; Weaver, Scott C.; Barrett, Alan D.T.
- Abstract
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
- Subjects
MEXICO; GENOMES; WEST Nile virus; FLAVIVIRUSES; NUCLEOTIDES; AMINO acids; ANIMAL experimentation; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; MICE; GENETIC mutation; RESEARCH; MICROBIAL virulence; EVALUATION research
- Publication
Emerging Infectious Diseases, 2004, Vol 10, Issue 12, p2221
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1012.040647