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- Title
Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.
- Authors
Nishibe, Y.; Kaneko, H.; Suzuki, H.; Abe, T.; Matsuura, Y.; Takaku, H.
- Abstract
The wild-type baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects a range of mammalian cell types in vitro but does not replicate in these cells. The current study investigated the in vivo effect of AcMNPV in the mouse model of liver cirrhosis induced by the mutagen dimethylnitrosamine. Intraperitoneal injection of AcMNPV induced an immune response. The baculovirus was taken up by the liver and spleen where it suppressed liver injury and fibrosis through the induction of interferons. This study presents the first evidence of the feasibility of using baculovirus to treat liver cirrhosis.Gene Therapy (2008) 15, 990–997; doi:10.1038/gt.2008.29; published online 27 March 2008
- Subjects
LIVER; LIVER diseases; CIRRHOSIS of the liver; BACULOVIRUSES; MAMMALS; DIMETHYLNITROSAMINE; FIBROSIS; GENE therapy; THERAPEUTICS
- Publication
Gene Therapy, 2008, Vol 15, Issue 13, p990
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/gt.2008.29