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- Title
A REVIEW ON "DENDRIMERS AND ITS APPLICATIONS IN NOVEL DRUG DELIVERY SYSTEM".
- Authors
Majumdar, Arti; Nema, R. K.
- Abstract
Dendrimers are a new class of polymeric materials. A dendrimer is typically symmetrical around the core and often adopts a spherical three dimensional architecture that provides a high degree of surface functionality and versatility.Dendrimers have a well defined size, shape, molecular weight and monodispersity. These are compatible with drug moieties as well as bioactive molecules like DNA, heparin and other polyanions. The nanoscopic size and recognition abilities make dendrimers as ideal building blocks for self-assembly and selforganization systems. The cavities inside the dendritic structure can be modified to incorporate hydrophobic and hydrophilic drugs. The terminal groups are modified to attach antibodies and bioactive substances for targeting purpose along with providing miscibility, reactivity and solubility. Currently, dendrimers are of great interest for delivering drug molecules via different routes as a nanocarrier. Toxicity problems associated with cationic dendrimers are overcome by PEGylation, which neutralizes the charge on them. Dendrimers possess suitable properties to establish itself as a potential carrier for delivery of therapeutic agents irrespective of certain synthetic and regulatory constraints. Applications of dendrimers in a large variety of fields have been explored. This review contains various pharmaceutical applications of dendrimers in a novel drug delivery system.
- Subjects
DENDRIMERS in medicine; DRUG delivery systems; UNIFORM polymers; BIOACTIVE compounds; POLYANIONS; MOLECULAR self-assembly
- Publication
International Journal of Pharmacy & Life Sciences, 2016, Vol 7, Issue 9, p71
- ISSN
0976-7126
- Publication type
Article