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- Title
Biocatalytic α-Oxidation of Cyclic Amines and N-Methylanilines for the Synthesis of Lactams and Formamides.
- Authors
Zheng, Daijun; Zhou, Xiaojian; Cui, Baodong; Han, Wenyong; Wan, Nanwei; Chen, Yongzheng
- Abstract
An environmentally friendly method for the synthesis of lactams and formamides through the biocatalytic α-oxidation of amines was developed by employing Pseudomonas plecoglossicida ZMU-T04 as a biocatalyst. In this biocatalytic process, the α-oxidation of cyclic amines and N-methylanilines proceeded smoothly to give the corresponding amides in low to high yields. Furthermore, it was demonstrated that synthetic 3,4-dihydroquinolin-2(1 H)-one could be used as a key precursor of antidepressant bioactive molecules. The mechanism of this biocatalytic α-oxidation process was investigated by isotope- labeling experiments.
- Subjects
AMINES; OXIDATION; ANILINE; BIOCATALYSIS; LACTAMS; CHEMICAL synthesis; FORMAMIDE; REGIOSELECTIVITY (Chemistry)
- Publication
ChemCatChem, 2017, Vol 9, Issue 6, p937
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201601703