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- Title
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
- Authors
Dey, Devaveena; Bagarova, Jana; Hatsell, Sarah J.; Armstrong, Kelli A.; Huang, Lily; Ermann, Joerg; Vonner, Ashley J.; Yue Shen; Mohedas, Agustin H.; Lee, Arthur; Eekhoff, Elisabeth M. W.; van Schie, Annelies; Demay, Marie B.; Keller, Charles; Wagers, Amy J.; Economides, Aris N.; Yu, Paul B.
- Abstract
The article discusses research which identified nonoverlapping tissue-resident populations responsible for different anatomic phenotypes of fibrodysplasia ossificans progressive (FOP), a congentital heterotopic ossification (HO) syndrome caused by mutations of bone morphogenetic protein (BMP) type I receptor ACVR1. Topics discussed include causes of HO and sufficiency of muscle-resident Mx1+ progenitor lineages for intramuscular HO.
- Subjects
FIBRODYSPLASIA ossificans progressiva; BONE morphogenetic protein genetics; GENETIC disorders; CONGENITAL disorders; OSSIFICATION
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 366, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf1090