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- Title
Newborn screening for sickle cell disease: an innovative pilot program to improve child survival in Dar es Salaam, Tanzania.
- Authors
Nkya, Siana; Mtei, Lillian; Soka, Deogratias; Mdai, Vera; Mwakale, Promise B; Mrosso, Paul; Mchoropa, Issa; Rwezaula, Stella; Azayo, Mary; Ulenga, Nzovu; Ngido, Melkiory; Cox, Sharon E; D'Mello, Brenda S; Masanja, Honorati; Kabadi, Gregory S; Mbuya, Frederick; Mmbando, Bruno; Daniel, Yvonne; Streetly, Allison; Killewo, Japhet
- Abstract
Background Sickle cell disease (SCD) is a recognized cause of childhood mortality. Tanzania has the fifth highest incidence of SCD (with an estimated 11 000 SCD annual births) worldwide. Although newborn screening (NBS) for SCD and comprehensive healthcare have been shown to reduce under-5 mortality by up to 94% in high-income countries such as the USA, no country in Africa has maintained NBS for SCD as a national health program. The aims of this program were to establish and evaluate NBS-SCD as a health intervention in Tanzania and to determine the birth prevalence of SCD. Methods Muhimbili University of Health and Allied Sciences conducted NBS for SCD from January 2015 to November 2016. Dried blood spot samples were collected and tested for SCD using isoelectric focusing. Results Screening was conducted on 3981 newborns. Thirty-one (0.8%) babies had SCD, 505 (12.6%) had sickle cell trait and 26 (0.7%) had other hemoglobinopathies. Twenty-eight (90.3%) of the 31 newborns with SCD were enrolled for comprehensive healthcare. Conclusions This is the first report on NBS as a health program for SCD in Tanzania. The SCD birth prevalence of 8 per 1000 births is of public health significance. It is therefore important to conduct NBS for SCD with enrollment into a comprehensive care program.
- Subjects
TANZANIA; DAR es Salaam (Tanzania); SICKLE cell anemia; NEWBORN screening; SICKLE cell trait; ISOELECTRIC focusing; HIGH-income countries; HEALTH programs
- Publication
International Health (1876-3413), 2019, Vol 11, Issue 6, p589
- ISSN
1876-3413
- Publication type
Article
- DOI
10.1093/inthealth/ihz028