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- Title
Endothelial Dysfunction in Diabetes.
- Authors
AVOGARO, ANGELO; ALBIERO, MATTIA; MENEGAZZO, LISA; DE KREUTZENBERG, SAULA; FADINI, GIAN PAOLO
- Abstract
The article outlines the mechanisms of endothelial dysfunction in diabetes, the role of endothelial progenitor cells (EPC) in cardiovascular homeostasis and the implications of EPC alterations in diabetes. Due to the adverse effects of hyperglycemia and oxidative stress on vascular biology, there is high risk of cardiovascular disease in type 2 diabetes. The strongest stimulus for EPC mobilization is tissue ischemia. Weak bone marrow mobilization, decreased proliferation and shortened survival are mechanisms underlying EPC reduction.
- Subjects
ENDOTHELIUM; DIABETES; CELLS; HOMEOSTASIS; HYPERGLYCEMIA
- Publication
Diabetes Care, 2011, Vol 34, pS285
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc11-s239