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- Title
Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.
- Authors
Danzer, Enrico; Hoffman, Casey; D’Agostino, Jo Ann; Miller, Judith S.; Waqar, Lindsay N.; Gerdes, Marsha; Bernbaum, Judy C.; Rosenthal, Hannah; Rintoul, Natalie E.; Herkert, Lisa M.; Peranteau, William H.; Flake, Alan W.; Adzick, N. Scott; Hedrick, Holly L.
- Abstract
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.
- Subjects
AUTISM risk factors; DIAPHRAGMATIC hernia; GENETIC disorders; PROBABILITY theory; DISEASE prevalence; DISEASE complications
- Publication
Journal of Autism & Developmental Disorders, 2018, Vol 48, Issue 6, p2112
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-018-3472-6